Cannabis use is rising exponentially, but research shows that between 0.1% and 1% of Americans are allergic to this therapeutic plant and the number is rising. A study in Allergy found cannabis allergy prevalence is even higher among those with conditions like pollen allergies or atopic dermatitis. If you experience sneezing, congestion, rashes, or worse when exposed to cannabis, you may be one of the unlucky few with this allergy. This comprehensive guide covers everything from identifying symptoms to exploring effective treatment options recommended by medical professionals including allergists. Follow along as we dive into the science behind cannabis allergies, proper diagnosis, personalized management strategies, and potential treatment options through immunotherapy so you can continue enjoying cannabis safely and comfortably.
Cannabis allergies occur when immune cells erroneously identify compounds in the cannabis plant as harmful invaders. This triggers an overzealous immune response involving antibody production, histamine release, and activation of mast cells, leading to bothersome allergy symptoms.
Studies show the main allergens are proteins called Bet v 1 and Bet v 2, also found in birch pollen. These immunogenic proteins are most concentrated in the pollen, leaves, seeds, and flowers of cannabis plants. When inhaled, consumed, or contacting the skin, they can provoke an allergic reaction.
The human body naturally produces endocannabinoids like anandamide which control immune function. One theory suggests irregular endocannabinoid signaling may underlie cannabis allergies. More research is exploring this link.
Genetics likely play a role, as allergy diseases often run in families. Environment is another factor, as exposure to cannabis at a younger age may increase allergy risk. Cross-reactivity between cannabis proteins and other plant antigens also promotes sensitivity.
Cannabis allergies differ from cannabis hyperemesis syndrome and cannabinoid hyperemesis syndrome, which cause severe vomiting from heavy long-term cannabis use. True cannabis allergies involve an abnormal immune reaction, not toxicity.
Unfortunately, allergy prevalence is rising generally, including cannabis allergy as use increases. According to research in Clinical & Experimental Allergy, reactions can range from mild to severe. Respiratory symptoms are most common, but skin, GI, and ocular issues also frequently arise.
Cannabis allergies commonly manifest through:
Inhalation of cannabis smoke or vapor is the primary route triggering respiratory allergy symptoms.
Topical skin contact with cannabis plants, leaves, oils or resins leads to skin manifestations. Reactions are localized to areas of contact.
Consuming cannabis edibles, drinks, tinctures, or oils can provoke GI issues due to digestion of allergens.
Ocular symptoms arise from direct contact with hands or cannabis smoke after exposure. Similar to seasonal allergy eye problems.
According to AAAI, respiratory symptoms like wheezing, coughing, and chest tightness are most prevalent. Skin flushing and eye redness are also frequently reported. The onset and severity of symptoms is highly individualized, ranging from mild irritation to severe systemic reactions.
If you suspect you may have a cannabis allergy, see an allergist or immunologist for proper testing and diagnosis. Your physician will ask about your medical history, including:
Allergy testing can confirm or rule out cannabis as the allergen source:
These diagnostic tests help identify which parts of the cannabis plant you react to – for example, pollen, leaves, or flowers. This informs proper treatment approaches. Testing may need to be performed periodically, as allergy sensitivity can change over time. Accurate diagnosis is the first step in cannabis allergy management.
The most effective cannabis allergy relief is strict avoidance, if possible. But for some, eliminating cannabis entirely may not be feasible or desired. In that case, take measures to reduce exposure:
Additionally, the AAAAI recommends over-the-counter oral antihistamines like Diphenhydramine, Loratadine, or Cetirizine to control mild symptoms. Nasal steroid sprays like Fluticasone can relieve nasal and sinus congestion, runny nose, sneezing, and postnasal drip. Hydrocortisone creams manage minor skin reactions.
Avoid triggers for any comorbid conditions like asthma or seasonal allergies, which may worsen with cannabis exposure. Follow an allergy action plan created with your doctor specifying when and which medications to use if exposed. Carry emergency epinephrine if you have a history of anaphylaxis.
For moderate to severe cannabis allergies, immunotherapy offers long-term treatment and desensitization. Sublingual drops or tablets provide incremental cannabis allergen doses under the tongue to retrain the immune system’s responses over months to years. Allergy shots work similarly, directly injecting increasing allergen levels over time. Though more research is needed, these methods can provide lasting relief for cannabis allergies when properly administered under medical supervision. Lifestyle modifications should also be maintained.
Allergy shots involve incremental injections of a customized cannabis allergen extract. This slowly retrains the immune system to tolerate specific cannabis proteins.
The buildup phase starts with a low dose, which increases over weeks to months until reaching the maintenance concentration. Maintenance shots continue for 3-5 years. With this regimen, allergy shots can desensitize the immune response to cannabis allergens long-term.
Sublingual immunotherapy (SLIT) is an alternative option, delivering liquid cannabis allergen extracts in small doses under the tongue daily. The dosage incrementally increases until reaching the maintenance amount. SLIT reprograms immune cells to control inflammatory responses to cannabis.
Studies suggest SLIT could effectively treat cannabis pollen allergies. It is associated with fewer side effects than shots, but requires strict daily adherence. Downsides include cost and off-label use for cannabis allergy.
Discuss these immunotherapy options with your allergist to decide if appropriate for your situation. Though data is limited for cannabis allergies specifically, these methods show efficacy for environmental allergies by inducing immunologic tolerance over time.
Cannabis allergies can be bothersome, but with proper precautions and treatment, you can still use cannabis safely. Work closely with healthcare providers to diagnose, manage, and treat cannabis allergies appropriately. With vigilance, protective measures, medications, and immunotherapy where warranted, you can pinpoint your triggers and reduce symptoms to safely use cannabis. Don’t let allergies prevent you from experiencing cannabis’ benefits.
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